It synthesizes knowledge and discoveries from decades of research made by many labs worldwide on Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, ALS, frontal temporal dementia, etc. Titled “Alternative Splicing in Neurodegenerative Disease and the Promise of RNA Therapies,” their review aims at providing comprehensive, all-inclusive knowledge for a scientific audience interested in the topic. They argue that since aberrant splicing dysregulation occurs commonly in neurodegenerative disease, the promise of using RNA therapies is important to understand and well-suited for a review. They also summarize the latest advances in RNA-based therapeutic strategies to target these disorders.Īccording to them, the topic of alternative splicing in neurodegenerative disease is particularly relevant in view of the increasing frequency of neurodegenerative disease worldwide and the urgent need for novel approaches for their treatment and management. Progressing rapidly, the field of alternative splicing is a complex topic and the scientific literature on it is already extensive.ĭavid Nikom, a student in the UC Riverside Neuroscience Graduate Program, and his advisor, Sika Zheng, an associate professor of biomedical sciences in the UCR School of Medicine and director of the Center for RNA Biology and Medicine, have written a review in Nature Reviews Neuroscience to discuss emerging research and evidence of the roles of alternative splicing defects in major neurodegenerative diseases. Alternative splicing, a clever way a cell generates many different variations of messenger RNAs - single-stranded RNAs involved in protein synthesis - and proteins from the same stretch of DNA, plays an important role in molecular biology.
0 kommentar(er)
